Panadol Cold & Flu

Further Information

Seek medical advice before taking this product:

• In patients with mild to moderate kidney impairment and in those with hepatic impairment
  
• In patients with cardiovascular disease, arrhythmias, hypertension, hyperthyroidism, prostatic enlargement, diabetes, glaucoma,phaeochromocytoma, epilepsy, bronchitis, bronchiectasis and bronchial asthma
  
• In patients with glutathione depleted states such as sepsis
  
• If you are taking beta-blockers and other antihypertensive drugs or tricyclic antidepressants
  
• There have been reports of ischaemic colitis with pseudoephedrine. Pseudoephedrine should be discontinued immediately and medical advice sought if sudden abdominal pain, rectal bleeding or other symptoms of ischaemic colitis develop
  
• There have been rare cases of posterior reversible encephalopathy (PRES)/reversible cerebral vasoconstriction syndrome (RCVS) reported with sympathomimetic drugs, including pseudoephedrine. Symptoms reported included sudden onset of severe headache, nausea, vomiting, and visual disturbances. Most cases improved or resolved within a few days following appropriate treatment. Psuedoephedrine should be discontinued immediately and medical advice sought if signs/symptoms of PRES/RCVS develop.
  
• Chlorphenamine may increase the effects of alcohol and therefore concurrent use should be avoided.
  
• Concurrent use with drugs which cause sedation, such as anxiolytics and hypnotics may cause an increase in sedative effects, therefore medical advice should be sought before taking chlorphenamine concurrently with these medicines.
  
• If symptoms persist, medical advice must be sought.
  
• Keep out of sight and reach of children.

Caution is advised if paracetamol is administered concomitantly with flucloxacillin due to increased risk of high anion gap metabolic acidosis (HAGMA), particularly in patients with severe renal impairment, sepsis, malnutrition, and other sources of glutathione deficiency (e.g. chronic alcoholism), as well as those using maximum daily doses of paracetamol. Close monitoring, including measurement of urinary 5-oxoproline, is recommended.

Pseudoephedrine should be discontinued immediately, and medical advice sought if sudden abdominal pain, rectal bleeding, or other symptoms of ischaemic colitis develop.

This product contains 0.6 mg Sodium benzoate per tablet to be taken into consideration by patients on controlled Sodium diet. Use in children aged 12 to 17 years: Paracetamol should not be taken for more than 48 hours.