Panadol Joint (Osteoarthritis Pain Relief)

This medicine may not be right for you. Read the label before purchasing. Follow the directions for use. Incorrect use could be harmful. Consult your healthcare professional if symptoms persist.

Before you take Panadol Joint

a. Do not take Panadol Joint in case of:
Known or previous history of hypersensitivity to paracetamol, or any other ingredient in the
product.

b. Take special care with Panadol Joint if:

• You have been diagnosed with liver or kidney impairment (Because Paracetamol is
  metabolised in the liver and excreted by the kidney in urine).

Paracetamol overdose may cause liver failure which may require liver transplant or lead to death. 

Underlying liver disease increases the risk of Paracetamol related liver damage

• Your symptoms do not improve, get worsen or new symptoms persist, you must
  consult your doctor as these could be signs of serious condition.
• Caution is advised if paracetamol is administered concomitantly with flucloxacillin due
  to increased risk of high anion gap metabolic acidosis (HAGMA), particularly in patients
  with severe renal impairment, sepsis, malnutrition and other sources of glutathione
  deficiency (e.g. chronic alcoholism), as well as those using maximum daily doses of
  paracetamol. Close monitoring, including measurement of urinary 5-oxoproline, is
  recommended.

Check with your doctor if:

• You have glutathione depleted states such as sepsis ,severely malnourished , anorexic, have low body mass index or chronic heavy users of alcohol or you have a severe infection as the use of Paracetamol may increase the risk of metabolic acidosis.

Signs of metabolic acidosis include:

• Deep, rapid, difficult breathing
• Feeling sick (nausea), being sick (vomiting)
• Loss of appetite
• Contact a doctor immediately if you get a combination of these symptoms.
• Keep this and all medication out of sight and reach of children.
• Do not exceed the stated dose.
• This product contains Paracetamol, do not take with any other product containing Paracetamol. The concomitant use with other products containing paracetamol may lead to an overdose.

c. Taking other medicines:

• The liver toxic effects of Paracetamol may be increased by the use of alcohol.
• The anticoagulant effect of warfarin and other coumarins may be enhanced by prolonged regular daily use of paracetamol with increased risk of bleeding; occasional doses have no significant effect.
• Paracetamol absorption is increased by substances that increase gastric emptying, eg metoclopramide.
• Paracetamol absorption is decreased by substances that decrease gastric emptying, eg propantheline, antidepressants with anticholinergic properties and narcotic analgesics.
• Paracetamol may increase chloramphenicol concentrations.
• The risk of Paracetamol toxicity may be increased in patients receiving other potentially hepatotoxic drugs or drugs that induce liver microsomal enzymes such as alcohol and anticonvulsant drugs.
• Paracetamol excretion may be affected and plasma concentrations altered when given with probenecid
• Colestyramine reduces the absorption of Paracetamol if given within one hour of Paracetamol.

Please inform your doctor or pharmacist if you are taking:

• flucloxacillin (antibiotic), due to a serious risk of blood and fluid abnormality (high anion gap metabolic acidosis) that must have urgent treatment and which may occur particularly in case of severe renal impairment, sepsis (when bacteria and their toxins circulate in the blood leading to organ damage), malnutrition, chronic alcoholism, and if the maximum daily doses of paracetamol are used.

d. Pregnancy & breast feeding:

As with the use of any medicine during pregnancy, pregnant women should seek medical advice before taking paracetamol. The lowest effective dose and shortest duration of treatment should be considered. Paracetamol is excreted in breast milk but not in a clinically significant amount at recommended dosages. Available published data do not contraindicate breastfeeding.

e. Driving and using machines:

Panadol Joint is unlikely to cause an effect on ability to drive and use machines.

Possible Adverse events
These reactions are very rare.

Stop using Panadol Joint and consult your doctor immediately if:

• You experience allergic reactions such as skin rash or itching, sometimes with breathing problems or swelling of the lips, tongue, throat or face.
• You experience Anaphylaxis, cutaneous hypersensitivity reactions including, among others, skin rashes, angiodema, Stevens–Johnson syndrome and Toxic Epidermal Necrolysis 
• You experience a skin rash or peeling or mouth ulcers.
• You have previously experienced breathing problems or bronchospasm with acetylsalicylic acid or non-steroidal anti-inflammatory, and experience a similar reaction with this product.
• You experience unexplained bruising or bleeding.
• You experienced liver dysfunction related symptoms or signs.

Can I take this medicine on an empty stomach?

Yes, you can take Panadol Joint on an empty stomach, as the active ingredient – paracetamol – is gentle on the stomach when used as directed.

Does Panadol Joint have any other uses (besides osteoarthritis pain relief)?

Panadol Joint has been specially developed to provide pain-release associated with osteoarthritis. With its sustained release technology it works with your body to help your symptoms subside. Panodol Joint can be used for other types of pain but we know no pain is the same. Be it a headache or a period cramp, we’d recommend you look for the exact product you need here.

Is Panadol Joint safe for long-term use?

The decision to use any medicine on a long-term basis is one best made with your doctor. They may want to discuss alternative options with you, or monitor you while you take the medication.

Are there any home remedies I can try for osteoarthritis pain relief?

Yes, there are lots of things you can try, including exercise, weight management, topical creams/gels and complementary medicines. Talk to your doctor or pharmacist for further guidance.

How should I store this medicine?

You should store Panadol Joint below 30 degrees Celsius.

How should I dispose of the empty bottle/packaging?

Please refer to the product label to see if the bottle/packaging is recyclable – and if it is, please do! Let’s look after our planet, so she can continue to look after us.