Panadol Actifast

The active ingredient in Panadol Actifast is paracetamol (500mg per tablet). Panadol Actifast also contain sodium bicarbonate (each tablet contains 173mg of sodium/346mg sodium per 2 tablet dose), which should be taken into account by those on a low-sodium diet, and potassium sorbate (a preservative).

 

 

If you are on a low-sodium diet, bear in mind that 8 tablets contain 1.4g (60mmol) of sodium.

Always read and follow all directions on the product label prior to use, and talk to your doctor or pharmacist if you’re not sure whether this medicine is right for you. Use only as directed. Incorrect use could be harmful. For the temporary relief of pain and fever. Consult your healthcare professional if symptoms persist (e.g. if you have a fever that comes and goes, or pain that is not relieved by treatment).

Before you take Panadol Actifast

a. Do not take Panadol Actifast in case of:

• Known or previous history of hypersensitivity to paracetamol or any other ingredients.
• Sever Hepatotoxicity.

b. Take special care with Panadol Actifast:

• This product contains Paracetamol. Do not use with any other paracetamolcontaining
  products. The concomitant use with other products containing
  paracetamol may lead to an overdose. Paracetamol overdose may cause liver
  failure which can lead to liver transplant or death.
• Cases of hepatic dysfunction/failure have been reported in patients with
  depleted glutathione levels, such as those who are severely malnourished,
  anorexic, have a low body mass index or are chronic heavy users of alcohol.
• Caution in patients with glutathione depleted states such as sepsis; the use of
  paracetamol may increase the risk of metabolic acidosis.
• This medicinal product contains 352 mg of sodium per dose, equivalent
  to 17.6% of the WHO recommended maximum daily intake for sodium.
  The maximum daily dose of this product is equivalent to 70.4% of the
  WHO recommended maximum daily intake for sodium. Panadol Actifast is
  considered high in sodium. This should be particularly taken into account for
  those on a low salt diet.
• Caution is advised if paracetamol is administered concomitantly with
  flucloxacillin due to increased risk of high anion gap metabolic acidosis
  (HAGMA), particularly in patients with severe renal impairment, sepsis,
  malnutrition and other sources of glutathione deficiency (e.g. chronic
  alcoholism), as well as those using maximum daily doses of paracetamol. Close
  monitoring, including measurement of urinary 5-oxoproline, is recommended.
• Underlying liver disease increases the risk of paracetamol-related liver damage.
  Patients who have been diagnosed with liver or kidney impairment must seek
  medical advice before taking this medication.
• If symptoms persist, seek medical advice. Prolonged use except under medical
  supervision may be harmful.
• Keep out of sight and reach of children.

c. Taking other medicines:

The speed of absorption of paracetamol may be increased by metoclopramide or
domperidone and absorption reduced by cholestyramine. The anticoagulant effect
of warfarin and other coumarins may be enhanced by prolonged regular daily use of
paracetamol with increased risk of bleeding; occasional doses have no significant effect.
Please inform your doctor or pharmacist if you are taking:

• flucloxacillin (antibiotic), due to a serious risk of blood and fluid abnormality
  (high anion gap metabolic acidosis) that must have urgent treatment and
  which may occur particularly in case of severe renal impairment, sepsis
  (when bacteria and their toxins circulate in the blood leading to organ
  damage), malnutrition, chronic alcoholism, and if the maximum daily doses of
  paracetamol are used.

d. Pregnancy & breast feeding:

• Human and animal studies with paracetamol have not identified any risk
  to pregnancy or embryo-foetal development or lactation or the breast-fed
  offspring. Paracetamol crosses the placental barrier and is excreted in breast
  milk.Seek medical advice before taking this product if you are pregnant or
  breast feeding.
• Paracetamol is excreted in breast milk. However, the level of paracetamol
  present is not considered to be harmful. Available published data do not
  contraindicate breastfeeding.

e. Ability to perform tasks that require judgment, motor or cognitive skills:

• No significant effect on ability to drive or use machines.
  Possible side effects

Events reported from extensive post-marketing experience at therapeutic/labelled dose and considered attributable are mentioned below by System Organ Class and frequency.

Frequencies are defined as: very common (≥1/10), common (≥1/100, <1/10), uncommon (≥1/1,000, <1/100), rare (≥1/10,000, <1/1000), very rare <1/10,000), not known (cannot be estimated from available data).

Adverse event frequencies have been estimated from spontaneous reports received through post-marketing data.

Blood and lymphatic system disorders
Very rare: Thrombocytopaenia

Immune system disorders
Very rare: Anaphylaxis, cutaneous hypersensitivity reactions including, among others, skin rashes, angioedema and Stevens Johnson syndrome and Toxic Epidermal Necrolysis. Very rare cases of serious skin reactions have been reported

Respiratory, thoracic and mediastinal disorders
Very rare: bronchospasm in patients sensitive to aspirin and other NSAIDs

Hepatobiliary disorders
Very rare: Hepatic dysfunction